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Invitrogen
AFP Monoclonal Antibody (10B8)
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产品信息
HYB 097-04-02
产品规格
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
10B8
抗原
Human alpha fetoprotein isolated from amniotic fluid.
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
4°C, store in dark
运输条件
Wet ice
RRID
产品详细信息
HYB 097-04-02 detects alpha fetoprotein from human samples. Cross-reactivity to other species or similar molecules have not been investigated.
HYB 097-04-02 has been successfully used in ELISA procedures. Ka=190, determined as concentration of antibody giving half-maximal binding to hepatoma-AFP bound to solid phase (unit: 108 L/mol). HYB 097-04-02 reacts strongly with human AFP. Strong reaction is seen when tested in sandwich ELISA in combination with a polyclonal antibody against human AFP (eg. DAKO A0008).
The HYB 097-04-02 immunogen is human alpha-fetoprotein isolated from amniotic fluid.
The epitope belongs to group II, a different group from HYB 097-05-02, 097-06-02, 097-08-02 and 097-09-02.
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
靶标信息
AFP (Alpha Fetoprotein) is a major plasma protein produced by the yolk sac, intestinal tract and the liver during fetal life. AFP expression in adults is often associated with hepatoma or teratoma. However, hereditary persistence of AFP may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and AFP and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. AFP is found in monomeric, dimeric, and trimeric forms. AFP can also bind to copper ions, nickel ions, fatty acids and bilirubin. The level of AFP in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. High level of serum AFP has been identified in patients with hepatocellular carcinomas (HCC), teratoblastoma, colorectal cancer, pancreatic cancer, and germ cell neoplasms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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